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Background: Periodontitis is a bacterial infection of tooth-supporting tissues; the immunopathologic mechanisms
include inflammatory cells and chemical mediators, which persist inflammation and develop a local autoimmune.
The presence of autoantibodies against extracellular matrix components, anti-neutrophil cytoplasmic antibodies
(ANCA) and anti-DNA was detected. This study aimed to provide evidence of altered humoral immune response in
chronic periodontitis, as well as to determine the presence of auto-antibodies in this disease.
Subjects and Methods: Blood samples were collected from 35 patients with chronic periodontitis (20 with sever
periodontitis and 15 with moderate periodontitis) and from 30 healthy age and sex matched individuals served as
controls. Clinical periodontal parameters used in this study were plaque index, gingival index, probing pocket depth,
clinical attachment level and bleeding on probing. The levels of serum IgG-antinuclear antibody were determined
using enzyme-linked immunosorbent assays, whereas serum immunoglobulin (IgG, IgM and IgA) were estimated by
single radial immune diffusion method.
Results: Serum levels of IgG-antinuclear antibody and IgG were significantly higher in sever chronic periodontitis than
in moderate chronic periodontitis and healthy controls (p<0.05). On the other hand, the serum levels of IgM and IgA
showed no significant differences among three studied groups (p>0.05). Concerning the correlation between serum
IgG-antinuclear antibody and clinical periodontal parameters, the level of this autoantibody did not show any
correlation with clinical parameters of periodontitis (p>0.05).
Conclusion: The production of antibodies against self structures could be involved in the pathogenic mechanism of
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