The role of lipid peroxidation in the inducation and progression of chronic periodontitis.

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Taghreed F Zaidan


Backgrounds: Free-radical-induced lipid peroxidation has been implicated in the pathogenesis of several pathological disorders. This study was aimed to assess the degree of oxidative stress in patients with chronic periodontitis by estimation of plasma and saliva lipid peroxidation product malondialdehyde (MDA), and the antioxidants erythrocyte glutathione (GSH), plasma and saliva thiol.
Patients and methods: Fifty patients with chronic periodontitis with mean age of 32.6 10.3 years and fifty healthy control subjects with normal gingival age study, 5 mls of blood and 3 mls of unstimulated saliva was collected from each subjects for estimation of plasma and saliva MDA, thiol and erythrocyte glutathione spectrophotometricaly.
Results: The results showed that significantly increased p<0.001 in periodontitis patient than in the control subjects, while erythrocyte glutathione, plasma and saliva thiol were significantly decreased p<0.05 in periodontitis patients than in the control.
Conclusions: Patients with periodontitis demonstrate more lipid peroxidation than healthy subjects. Imbalance between oxidative stress and antioxidants may play a role in the pathogenesis of perodontitis.

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